UCLA researchers eliminate major roadblock in regenerative medicine (1/25/2011)

UCLA researchers, including MSL members Dr. Hideaki Tsutsui and Prof. Chih-Ming Ho, developed a new chemically defined culture system for human embryonic stem (hES) cells. They successfully applied the Feedback System Control scheme to identify an optimal combination of small molecule inhibitors that can support survival and growth of hES cells under a clinically enabling, defined condition. This work was published in the January 25th issue of Nature Communications, and has been since picked up by more than 50 online news sites.

A list of selected news articles:

  • UCLA Newsroom, “UCLA researchers eliminate major roadblock in regenerative medicine”
  • ScienceDaily, “Regenerative Medicine Advance: New ‘Cocktails’ Support Long-Term Maintenance of Human Embryonic Stem Cells”
  • Medill Report Chicago, “Discovery brings embryonic stem cells closer to mainstream medicine”
  • Daily Bruin, “UCLA scientists develop a new cell-culture system that allows for much more precise research”
  • Genetic Engineering & Biotechnology News, “Animal-free culture system for single-cell passaging of hESCs developed”
  • UCLA News Week (Video News)
  • 2011

    Journal Publications top

    Wong T.-S., Chen T.-H.,  Shen X., and Ho C.M., “Nanochromatography Driven by the coffee Ring Effect,“ Analytical Chemistry, vol. 83, pp. 1871–1873, 2011.

    Valamehr, B., Tsutsui, H., Ho, C.M., and Wu, H., “Developing Defined Culture Systems for Human Pluripotent Stem Cells,” Regenerative Medicine, Vol. 6, pp. 623-634, 2011.

    Tsutsui, H., Valamehr, B., Hindoyan, A., Qiao, R., Ding, X., Guo, S., Witte, O.N., Liu, X., Ho, C.M., and Wu, H., “An Optimized Small Molecule Inhibitor Cocktail Supports Long-term Maintenance of Human Embryonic Stem Cells,” Nature Communications, 2:167, DOI:10.1038/ncomms1165, 2011.

    Wu, Chunsheng, Lillehoj, P.B., Sabet, L., Wang, P. and Ho, C.M., “Ultrasonication on a microfluidic chip to lyse single and multiple Pseudo-nitzschia for marine biotoxin analysis“, Biotechnology Journal, 5(2): 150-155, 2011.

    Al-Shyoukh, I., Yu, F., Feng, J., Yan, K., Dubinett, S., Ho, C. M., Shamma, J.S. and Sun R., “Systematic quantitative characterization of cellular responses induced by multiple signals“, BMC Systems Biology, Vol. 5, pp. 88, 2011.

    Yu, F., Al-Shyoukh, I., Feng, J., Li, X., Liao, C.W., Ho, C.M., Shamma, J.S., Sun R., “Control of Kaposi’s Sarcoma-Associated Herpesvirus Reactivation Induced by Multiple Signals”, Plos ONE, Vol. 6, Issue 6, pp. 1-13, 2011.

    Lee, J., Newbern, S., Tai, Y.C., Ho, C.M., and Huang, P.H., “Flight demonstrations of micro-actuator controlled delta wing”, Aircraft Engineering and Aerospace Technology, Vol. 83, Issue 5, pp. 324-331, 2011.

    Haulot. G. and Ho, C.M.,“Optoelectronic Heating for Fabricating Microfluidic Circuitry”, Advances in OptoElectronics, Volume 2011, Article ID 237026, doi:10.1155/2011/237026, 2011.

    Wei, F., Bai, B., and Ho, C. M., “Rapidly optimizing an aptamer based BoNT sensor by feedback system control (FSC) scheme”, Biosensors and Bioelectronics, Vol. 30, pp. 174-179, 2011.