Ting-Hsuan Chen

Vitatop

I was born in Taiwan and attended Chien Kuo High School for my high school studies. I received Bachelor’s degree (2003) in Power Mechanical Engineering and and Master degree (2005) in Institute of MEMS from the National Tsing Hua University. During the years in college, the interests in MEMS and fluid mechanics led me to the field of BioMEMS, where I worked on my Master thesis under the supervision of Professor Fan-Gang Tseng. Later, I joined University of California Los Angeles and completed my PhD degree under Professor Chih-Ming Ho from 2007 – 2012. In the early phase of my researches, I constructed a deformable metal/polymer membrane with hydrophobic posts to reversibly change the surface morphology as well as the wettability. I was also involved in characterization of electrochemical sensors and a separation mechanisms for biological entities using coffee ring effect. For my dissertation, my research focus on approaches which correlate cardiology, mathematics and microengineering to investigate the self-organized pattern formation formed by multicellular tissue. This interdisciplinary research will potentially provide platforms aiming at fundamental questions and impact the fields such as tissue engineering, regenerative medicine, cardiology disease and cancer.

Research Intereststop

Systems that consist of vast number of interactive components and possess self-organized capabilities are commonly regarded as complex systems. Tissue, as a biological complex system, composed of cells, growth factors and extracellular matrix, exhibits its functionalities via an orchestration of self-organized activities with unique spatiotemporal coordination. How could we understand it? Analogous to turbulent flow, the emergent behaviors from “single” to “multiple” is one of the core function in complex systems, in which the bifurcation is highly dependent on the initial perturbation. With the aids of mathematics and microengineerings, we are allowed to investigate the biological phenomena down to the reorganization of cytoskeletal structure, and move upward to tissue morphology. Specifically, BioMEMS was utilized to create an artificial microenvironment for applying mechanical perturbation in single cell level. Subsequently, mathematics explains the non-linear dynamics in the development toward the global tissue level. These multidisplinary subjects enables us to be accessible to challenges such as tissue regeneration and cancer.

Educationtop

Ph.D., Mechanical Engineering, University of California, Los Angeles, USA (9/2007 – 3/2012)

M.S., Institute of MEMS, National Tsing Hua University, Taiwan (9/2003 – 6/2005)

B.S., Power Mechanical Engineering, National Tsing Hua University, Taiwan (9/1999 – 6/2003)

Work Experiencetop

Postdoctoral Scholar (04/2012 – Present)
Molecular Mechanics Laboratory, University of California, Los Angeles

Graduate Student Researcher (09/2007 – 03/2012)
Molecular Mechanics Laboratory, University of California, Los Angeles

Associate Engineer (06/2006 – 07/2007)
Industrial Technology Research Institute

Research Assistant (09/2003 – 01/2006)
Nano/Micro Bio-Optic-Electro-Mechanical System and Fluidics LAB

Patents and Publicationstop

Degree Thesis:

Ting-Hsuan Chen, “Top-down engineering of self-organizing cell pattern formation for regenerative medicine,” Ph.D. Dissertation, University of California, Los Angeles, 2012.

Ting-Hsuan Chen, “Micro droplet actuator driven by dynamic surface roughness effect,” Master Thesis, National Tsing-Hua University, Taiwan, 2005.

Journal Publications:

Margaret Wong, Timothy Nguyen, Ting-Hsuan Chen, Jeffrey Hsu, Xingjuan Zeng, Aman Saw, Eric Demer, Xin Zhao, Yin Tintut, Linda Demer, “Preferred Mitotic Orientation in Pattern Formation by Vascular Mesenchymal Cells”, American Journal of Physiology – Heart and Circulatory Physiology, accepted, in press (IF: 3.7).

Ting-Hsuan Chen, Xiaolu Zhu, Leiting Pan, Xingjuan Zeng, Alan Garfinkel, Yin Tintut, Linda L Demer, Xin Zhao, Chih-Ming Ho, “Directing Tissue Morphogenesis via Self-Assembly of Vascular Mesenchymal Cells,” Biomaterials, vol. 33, pp. 2019-2026, 2012 (IF:7.4).

Ting-Hsuan Chen, Jeffrey J. Hsu, Xin Zhao, Chunyan Guo, Margaret Wong, Yi Huang, Zongwei Li, Alan Garfinkel, Chih-Ming Ho, Yin Tintut, Linda L. Demer, “Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics,” Circulation Research, vol. 110, pp. 551–559, 2012 (Cover image; IF:10.2; Editor’s picks in the issue; Rated as top 2% of published articles in biology and medicine by Faculty of 1000; The most downloaded original article from the Feb 17th, 2012 issue).

Ting-Hsuan Chen, Chunyan Guo, Xin Zhao, Yucheng Yao, Kristina I. Bostrom, Margaret N. Wong, Yin Tintut, Linda L. Demer, Chih-Ming Ho, Alan Garfinkel, “Patterns of periodic holes created by increased cell motility,” Interface Focus, vol. 2, pp. 457-64, 2012 (Sister journal recently isolated from Journal of the Royal Society Interface, which has IF: 4.3)

Tak-Sing Wong, Ting-Hsuan Chen (co-first author), Xiaoying Shen, and Chih-Ming Ho. “Nanochromatography Driven by the Coffee Ring Effect,“ Analytical Chemistry, vol. 83, pp. 1871–1873, 2011 (IF: 5.9; 4th place of top 20 most read article in July 2011)

Daniel E. Garcia., Ting-Hsuan Chen., Fang Wei, and Chih-Ming Ho, “A Parametric Design Study of an Electrochemical Sensor,“ Journal Laboratory Automation, vol. 15, pp. 179-188, 2010

Ting-Hsuan Chen, Yun-Ju Chuang, Ching-Chang Chieng and Fan-Gang Tseng, “A Wettability Switchable Surface By Micro Surface Morphology Change,” Journal of Micromechanics and Microengineering, vol. 17, pp. 489 – 495, 2007

International Conference:
Ting-Hsuan Chen, Margaret Wong, Yin Tintut, Linda L. Demer, and Chih-Ming Ho, “Cell Pattern Formation Controlled By Microscale Interfaces,” The 25th IEEE International Conference on Microelectromechanical Systems, MEMS’12, Paris, France, Jan., 2012.

Ting-Hsuan Chen, Fang Wei and Chih-Ming Ho, “NEAR-FIELD ION FLOW FOR MOLECULAR SCALE MANIPULATION,” Solid-State Sensors, Actuators and microsystems Conference, TRANSDUCERS, Denver, USA, Jun., 2009.

Ting-Hsuan Chen, Chun-Min Su, Win-Ti Lin, Cheng-Tsai Yang, “A Novel Passive Pressure-Relief Valve for Blood Pressure Monitor,” 35th International MATADOR, Taipei, Taiwan ROC, Jul., 2007

Ting-Hsuan Chen, Chun-Min Su, Hsuei-Ching Chih, Cheng-Tsai Yang, “Selective Wettability assisted Nanoliter Sample Generation via Electrowetting-Based Transportation,” 5th International Conference on Nanochannels, Microchannels and Minichannels, ICNMM’07, Puebla, Mexico, Jun., 2007

Chun-Min Su, Ting-Hsuan Chen, Cheng-Tsai Yang, “Air Piston Calibrator for Microflow Delivery and Measurement Systems,” 5th International Conference on Nanochannels, Microchannels and Minichannels, ICNMM’07, Puebla, Mexico, Jun., 2007

Chih-Cheng Feng, Hsurh-Ching Shih, Ting-Hsuan Chen and Li-Yu Chu, “Droplet Handling for SPR Instrument Using Single-Side Electrowetting,” International Symposium on Nano Science and Technology, ISNST’06, Tainan, Taiwan ROC, Nov., 2006, pp. 82-83.

Ting-Hsuan Chen, Yun-Ju Chuang and Fan-Gang Tseng, “A Nano-Structrued Conductive, Antireflective, and Superhydrophobic Polymer Membrane Composed of PDMS and Carbon-Nano-Tube,” 3rd Asia-Pacific Conference of Transducers and Micro-Nano Technology, APCOT’06, Singapore, Jun., 2006.

Ting-Hsuan Chen, Yun-Ju Chuang and Fan-Gang Tseng, “A Novel Fabrication Method of 3D Polymer Multilayer Structures with Thin Movable Metal/PDMS Composite Membrane and its Application on Electrostatic Actuator,” 2nd International Symposium on Micro & Nano Technology, ISMNT’06, Hsinchu, Taiwan ROC, Mar., 2006.

Ting-Hsuan Chen, Yun-Ju Chuang and Fan-Gang Tseng, “A Wettability Switchable Surface Driven By Electrostatic Induced Surface Morphology Change Without Energy Interference on Reagents in Droplets” 19th IEEE International Conference on Microelectromechanical Systems, MEMS’06, Instanbul, Turkey, Jan., 2006, pp. 178-181.

Awards and Honorstop

Departmental Fellowship, Mechanical and Aerospace Engineering Department, UCLA, 2007

University Fellowship, UCLA, 2010-2011

Contact Infotop

Mailing Address:
15-155 Engineering IV
420 Westwood Plaza
Los Angeles, CA 90095Phone: (310) 825-9540
Fax: (310) 825-1350
Email: tinghsuan@ucla.edu