Xianting Ding, Ph.D.

My research interests have been focused on understanding and controlling complex systems, particularly biological systems and chemical systems. Complex systems such like cells involve multiple layers of intracellular signaling molecules. These molecules interact in a highly dynamic nonlinear way. Traditional drug development usually targets on a particular molecule, such as a piece of DNA or RNA, a protein, an individual signaling receptor at cell membrane, etc. Due to the intrinsic cellular complexity, this route has resulted in a low yield of successful new drug cases of less than 1%. Meanwhile, to decide the target, traditional biologists commonly spend years of bench work. In our lab, we developed an effective and rapid solution to identify optimal drug combinations. This new platform combines an engineering searching algorithm and bench experiments. We applied this platform technique to various cases, including Herpes Simplex Virus inhibition, oral cancer therapy, osteogenic medium development and currently Chinese herbal medicine studies. Generally, we were able to identify effective drug cocktails by testing less than 0.2% of the total possible drug combinations. We also applied this platform technique to the synthesis of AgI nanoparticles in microfluidics. AgI nanoparticles are important electrolytes for next generation battery. By combining our search platform and microfliudics channels, we successfully synthesized uniform AgI nanoparticles at less than 10nm.

University of California, Los Angeles, Los Angeles, California, 2009–2012
Ph.D. in Mechanical Engineering, Major: Micro-Electro-Mechanical Systems(MEMS)/Nanotechnology
Advisor: Prof. Chih-Ming Ho
Thesis: “A Top-down System Approach for Herpes Simplex Virus type 1 (HSV-1) inhibition”

University of California, Los Angeles, Los Angeles, California, 2007–2009
M.S. in Mechanical and Aerospace Engineering

Zhejiang University, Hangzhou, China, 2003–2007
B.S. in Mechanical Engineering, Major: Automation

Jun. 2012 Xianting Ding, Yi-Kuen Lee, Karl Tsim, Hui Yu, and Chih-Ming Ho, “Optimizing traditional Chinese herbal medicines for increasing human red blood cells”, Chinese national patent pending

Jan. 2011 Xianting Ding, Jian Yang, and Ieong Wong, “Synthesis of uniform AgI nanoparticles with complexant-free combinatorial surfactants”, U.S. provisional patent; U.S. national patent pending

Jun. 2010 Xianting Ding, Ieong Wong and Chih-Ming Ho, “A Fast, high throughput method for single bacterial patterning on glass surface”, U.S. provisional patent; U.S. national patent pending

Oct. 2009 Xianting Ding, David J Sanchez, Genhong Cheng and Chih-Ming Ho, “Case-specific optimal combinatory drug screening in HSV-1 inhibition”, U.S. provisional patent; U.S. national patent pending

2012 Chinese-American Engineers and Scientists Association of Southern California (CESASC) Scholarship (8 out of 200 applicants)

2012 Art of Science Contest Honorable Prize, Journal of Laboratory Automation (JALA) & JBS

2011-2012 California State Science Fair (CSSF) Judge Award, California Science Center

2008 BD FACS Canto II Operator Certificate, BD Biosciences Company

2007 Doctoral Fellowship, University of California Los Angeles

2004-2006 First Class Scholarship of Zhejiang University (continuously received for 3 years, top 0.1% of the university)

2004-2006 Zhejiang University outstanding students (continuously received for 3 years, top 0.1% of the university)

2006 Chinese Academy of Sciences (SAS) scholarship (3 out of 500 applicants)

2006 Global College Student Mathematical Contest in Modeling Participant Award

2005 Zhejiang University Mathematical Contest in Modeling First Prize

2005 China National Mathematical Contest in Modeling Second Prize

2005 China HP outstanding student scholarship (3 out of 200 applicants), HP China

2004 Zhejiang Province Calculus Competition Excellence Award, Zhejiang Province

2004 outstanding student cadre, Zhejiang University

Postdoctoral Researcher (March 2012 – Now)
Mechanical and Aerospace Engineering Department, University of California, Los Angeles
• Apply Feedback System Control (FSC) platform technology to optimize drug combinations for various disease, including oral cancer, bladder cancer, Herpes virus, C. Elegans worms, etc.

Graduate Student Researcher (September 2007 – March 2012)
Mechanical and Aerospace Engineering Department, University of California, Los Angeles
• Developed an effective and rapid platform for identifying combinatorial drugs for Herpes Simplex Virus inhibition
• Developed surface chemical treatment to pattern single E.coli on glass surfaces
• Developed microfluidic systems to synthesize uniform AgI nanoparticles at < 10 nm

Undergraduate Student Researcher (September 2005 – July 2007)
Mechanical Engineering Department, Zhejiang University, China
• Investigated liquid parameters using spinning liquid method
• Co-developed an online laboratory

JOURNAL PUBLICATIONS:

1. Xianting Ding, David Jesse Sanchez, Arash Shahangian, Genhong Cheng and Chih-Ming Ho, “Cascade search for HSV-1combinatorial drugs with high antiviral efficacy and low toxicity”, International Journal of Nanomedicine, vol. 7, pp 2281-2292 (2012). [1322 downloads within 3 months of publication]

2. Jessica Jaynes, Xianting Ding, Hongquan Xu, Weng Kee Wong and Chih-Ming Ho, “Using Fractional Factorial Designs to Study Drug Combinations”, Statistics in Medicine, DOI: 10.1002/sim.5526 (2012)

3. Xianting Ding, Hongquan Xu,Chanelle Hopper,Jian Yang and Chih-Ming Ho, “Use of Fractional Factorial Designs in Antiviral Drug Studies”, Quality and Reliability Engineering International, DOI: 10.1002/qre.1308 (2012)

4. Ieong Wong , Xianting Ding (co-first author), Chunsheng Wu and Chih-Ming Ho “Accurate and Effective Live Bacteria Microarray Patterning on Thick Polycationic Polymer Layer Co-Patterned with HMDS”, RSC Advances, Vol. 2, pp. 7673-7676 (2012)

5. Jianjun Ye, Jian Yang, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li and Cong Chen “Thermal transpiration effect on the mass transfer and flow behaviors of the pressure-driven hydrogen gas flow”, International Journal of Hydrogen Energy, Vol. 37, pp. 12474-12480 (2012)

6. Yoshitomo Honda, Xianting Ding, Federico Mussano, Akira Wiberg, Chih-ming Ho and Ichiro Nishimura, “Rapid stochastic identification of combinatory extrinsic factors for the fate commitment of mesenchymal stem cells through BMP-SMAD pathway”, in manuscript

7. Hongquan Xu, Jessica Jaynes and Xianting Ding, “Combining Two-Level and Three-Level Orthogonal Arrays for Factor Screening and Response Surface Exploration”, Journal of the American Statistical Association, in review

8. YE Jianjun, YANG Jian, ZHENG Jinyang, DING Xianting, WONG Ieong, LI Weizhong and CHEN Cong, “Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump,” Journal of Mechanical Engineering, Volume 25, Issue 4, pp 745-752 (2012)

9. Liu Gang, Yang Jian, Zheng Jin-Yang, Ding Xianting, Wong Ieong, Xu Chao and Guo Jin-Xing, “The fluid-structure interaction analysis of elbows under a transient liquid slug,” Journal of Engineering Thermophysics, Vol 31, pages 85-88 (2011)

10. Jianjun Ye, Jian Yang, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li and Cong Chen, “A multi-scale flow analysis in hydrogen separation membranes using a coupled DSMC-SPH method,” International Journal of Hydrogen Energy, Volume 37, Pages 894–902 (2011)

11. Hideaki Tsutsui, Bahram Valamehr, Antreas Hindoyan, Rong Qiao, Xiangting Ding, Shuling Guo, Rachel Kim, April Pyle, Amander Clark, Owen N. Witte, Xin Liu, Chih-Ming Ho and Hong Wu, “An Optimized Small Molecule Inhibitor Cocktail Supports Long-Term Maintenance Of Human Embryonic Stem Cells,” Nature Communication, Vol. 2: 167, doi:10.1038/ncomms1165 (2011)

PEER-REVIEWED INTERNATIONAL CONFERENCE PROCEEDINGS:
1. Ningxia Liu, Xianting Ding, Mingzhu Sun, Xin Zhao and Guizhang Lu, “Cells Tracking Based on Camshift and Active Contour Model”, the 31st Chinese Control Conference, Hefei, China, July, 2012

2. Jian Yang, Xianting Ding, Zhijun Ma, Weiping Wang, Ieong Wong and Chih-Ming Ho, “synthesis of scalable micro-droplets with fluid instability of shearing flow in microfluidics”, IEEE International Conference on Micro-Electro-Mechanical Systems (MEMS’13), Taibei, Taiwan, 2013 (in review)

3. Jianjun Ye, Jian Yang, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li and Cong Chen, “A multi-scale flow analysis in hydrogen separation membranes using a coupled DSMC-SPH method,” HyForum, Fukuoka, Japan, February, 2011

4. Yoshitomo Honda, Federico Mussano, Akira Wiberg, Xianting Ding, Chih-Ming Ho and Ichiro Nishimura, “Rapid Identification of combinatory osteogenic cocktails for mesenchymal stem cells”. International association for dental research (IADR’11) 89th Annual meeting, San Diego, California, U.S., March, 2011.

5. Xianting Ding, David Jesse Sanchez, Arash Shahangian, Genhong Cheng and Chih-Ming Ho, “Ablation of HSV-1 Replication by Drug Combinations Developed through Feedback System Control,” Biomedical Engineering Society (BMES’10) Annual Meeting, Austin, Texas, U.S., October, 2010

6. David Jesse Sanchez, Xianting Ding, Eric Schopf , Yang Liu, Jane C. Deng, Siyin Yang, Yong Cheng, Chih-Ming Ho and Genhong Cheng, “Harnessing Nanotechnology to Create New Diagnostics and Treatments for Infectious Disease,” IEEE Conference on Nanotechnology (NANO’03) 2010-joint symposium with NANO KOREA, Seoul, Korea, August, 2010

7. Jianjun Ye, Jian Yang, Ieong Wong, Xianting Ding, Jinyang zheng ,Weizhong Li and Cong Chen, “Multiscale Dynamic Analysis on the Structure of a Porous Silicon-based Membrane for Micro-fuel Cells,” 8th International Symposium on New Materials for Electrochemical Systems, Shanghai, China, July, 2010

Mailing Address:
18-111 Engineering IV
420 Westwood Plaza
Los Angeles, CA 90095

Contact:
Phone: 310-825-1350
Fax: 310-825-1350
Email: dingxianting@ucla.edu