Dr. Ieong Wong

After getting my bachelor degree in Aerospace Engineering with summa cum laude, I was awarded with the departmental fellowship and scholarship to continue my graduate study at UCLA. Fascinated by Professor Ho’s interdisciplinary research in fluid mechanics and nanotechnology, I joined Professor Ho’s Micro Systems Laboratories. During my PhD study, I focused on developing integrated microfluidic systems for microbiological and biomedical applications. After completing my PhD in 2009, I continue my research in the biomedical engineering domain and focus on complex biological and biochemical system optimization, computation, and modeling.

Research Experience top

Summary of Research Experience
• Current Projects: Stochastic Optimization and Modeling for Combinatorial Drug Therapy
• 15 Publications in Scientific Journals and Conferences
• Over 150 citations
• 1 Review Article
• 4 Patents Pending
• h-index: 5
• Mentored 7 Master and Undergraduate Student Researchers with Joint Publications
• Invited Reviewer for 5 Scientific Journals
• Member of Sigma Xi, The Scientific Research Society (2009 – Present)

Postdoctoral Research Scholar, Mechanical Engineering Department, UCLA, 2009-Present
Stochastic Optimization and Modeling for Combinatorial Drug Discovery
• Stochastic Optimization: Adaptive Differential Evolution Algorithm
• Combinatorial Optimization: Modeling and Optimization for Combinatorial Drug Therapy
• Statistics: Design of Experiment for Combinatorial Drug TherapySelf Organized System Computation, Modeling, and Characterizations:
• Chemical Computing with Self-Organized Chemical Systems
• Pattern Formation via Self Assembly of Heterotypic Cell-Cell Interactions
• Characterization of Learning Behavior on Scale Free Artificial Neural System
• Application of Nanotechnology on Self Organized Complex System

Graduate Student Researcher, Mechanical Engineering Department, UCLA, 2003-2009
Microfluidic Systems For Single Cell Microbiological Studies
• Fabrication of Microfluidic System for Single Cell Dynamic Study
• Morphological Studies of Biofuel Producing Bacteria at the Single Cell Level

Micro/Nanoscale Biochemical Surface Lithography for Single Cell Biological Studies
• Soft Lithography Based Surface Chemistry and Protein Micropatterning
• High Density Single Bacterium Glass Surface Patterning
• Surface Enhanced Raman Spectroscopy (SERS) Based Cell Kinase Activity Detection
• Dielectrophoresis in Hydrogel Defined Geometries for Stem Cells Study
• Microfluidics Based Two Dimensional Patterning of Small Peptides for Bacteria Screening

Educationtop

PhD in Mechanical Engineering
UCLA, 2003-2009
Field: Micro-Electro-Mechanical Systems (MEMS)/Nanotechnology
UCLA MEMS/Nanotechnology program ranked #2 in the world, 2004
Thomson Essential Science Indicators (http://www.esi‐topics.com/mems/inst/c1a.html)
Advisor: Professor Chih-Ming Ho
National Academy of Engineering
Featured by ISIHighlyCited

Dissertation: Integrated Micro Devices for Single-Cell Microbiology Studies
Graduate Departmental Fellowship and Scholarship (USD 20,000) for Distinguished Academic Records
10 Publications in Scientific Journals and Conferences, 1 Review Article, over 100 Citations

BS in Aerospace Engineering
UCLA, 1999-2003
Outstanding Bachelor of Science Award, Highest GPA of the Year
summa cum laude
Southern California Aerospace Coordinating Committee Scholarship

Professional Experiencetop

Journal Reviewer:
• Lab on a Chip
• Langmuir
• Nanotechnology
• IEEE Nanotechnology Magazine
• Journal of Physics D: Applied Physics
• Nature Biotechnology
• Advanced Materials
• Biosensors and Bioelectronics
• Physics of Fluids
• Journal of Micro Nano Mechatronics

Teaching Experience:
Teaching Assistant (2004)
Mechanical and Aerospace Engineering Department, University of California, Los Angeles
MAE102, Course Title: Fluid Mechanics
• Planned and led weekly discussion sections
• Held office hours, graded assignments, and proctored exams

Teaching Assistant (2000-2001)
Mathematics Department, Pasadena City College, Pasadena, CA
• Assisted instructors during lectures
• Graded assignments and exams, held office hours

Publicationstop

Journal Publications
1. Wong I, Ho C-M, Adaptive Population Based Differential Evolution Algorithm, submitted2. Zhang G-M, Wong I, Chou M-T, and Zhao X, “Towards Constructing Multi-Bit Binary Adder Based on Belousov-Zhabotinsky Reaction”, Journal of Chemical Physics, vol. 136, pp. 164108 (2012)

3. Wong I, Ding XT, Wu CS, Ho C-M, “Accurate and Effective Live Bacteria Microarray Patterning on Thick Polycationic Polymer Layer Co-Patterned with HMDS”, RSC Advances, Vol. 2, pp. 7673 – 7676 (2012)

4. Wong I, Wei F, Hecht A, Tsutsui H, and Ho C-M, “Soft Contact Molding: Co-patterning Functional Monolayers on Glass”, submitted to Langmuir

5. Wong I, Atsumi S, Huang W-C, Wu T-Y, Hanai T, Lam M-L, Tang P, Yang J, Liao J-C, and Ho C-M, “An Agar Gel Membrane-PDMS Hybrid Microfluidic Device for Long Term Single Cell Dynamic Study”, Lab on a Chip, vol. 10, pp. 2710-2719 (2010)

6. Tsutsui H, Yu E, Marquina S, Valamehr B, Wong I, Wu H, and Ho C-M, “Efficient Dielectrophoretic Patterning of Embryonic Stem Cells in Energy Landscapes Defined by Hydrogel Geometries”, Annals of Biomedical Engineering, vol. 38, pp. 3777-3788 (2010)

7. Yue ZC, Zhuang FF, Kumar R, Wong I, Cronin SB, and Liu Y-H, “Cell Kinase Activity Assay Based on Surface Enhanced Raman Spectroscopy”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 73, pp.226-230 (2009) [Top 25 Hottest Article of Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Apr-June 2009)]

8. Ye JJ, Yang J, Zheng JY, Ding XT, Wong I, Li WZ, and Chen C, “Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump”, Chinese Journal Of Mechanical Engineering, Vol. 25, pp. 745-752 (2012)

9. Ye JJ, Yang J, Zheng JY, Ding XT, Wong I, Li WZ, Chen C, “A Multi-scale Flow Analysis in Hydrogen Separation Membranes Using a Coupled DSMC-SPH Method”, International Journal of Hydrogen Energy, Vol. 37, pp. 894–902 (2012)

10. Yang J, Ye JJ, Zheng JY, Wong I, and Lam CK, “Using Direct Simulation Monte Carlo with Improved Boundary Conditions for Heat and Mass Transfer in Microchannels”, Journal of Heat Transfer – Transactions of ASME, vol. 132, pp. 041008 (2010)

11. Yang J, Ye JJ, Zheng JY, Wong I, Ma YB, Lam CK, Link S, “Improving DSMC with New Pressure Boundary Conditions for Heat and Mass Transfer of Microchannel Flows”, Nanoscale and Microscale Thermophysical Engineering, vol.13, pp.165 – 183 (2009)

12. Wong I and Ho C-M, “Surface Molecular Property Modifications for Poly(dimethylsiloxane) (PDMS) Based Microfluidic Devices”, Microfluidics and Nanofluidics, vol. 7, pp. 291 – 306 (2009)
[ Times Cited: 120 ]
[ Highly Cited and Most Downloaded Articles of Microfluidics and Nanofluidics ]
[ Reported in the official Watch Report of The Observatory for Micro and Nano Technologies (OMNT), a joint unit by the French National Center for Scientific Research (CNRS) and the French Atomic and Alternative Energies Commission (CEA), Micro & NanoSystems for Biology, N° 40, Dec 2009 ]

Conference Publications

1. Wong I and Ho C-M, “Self Assembled Monolayer Patterning Using Capillary Force Lithography”, Proceedings of 19th IEEE International Conference on Micro Electro Mechanical System (IEEE MEMS 2006), pp. 558-561, Istanbul, Turkey, January 22-26 (2006) [Conference Acceptance Rate 30%]

2. Ding X, Yang J, Ma ZJ, Liu DD, Wang WP, Ye JJ, Wong I, Barnes M, “Synthesis of Scalable Microdroplets with Fluid Instability of Shearing Flow in Microfluidics”, Proceedings of the 8th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS 2013), Suzhou, China, April 7-10 (2013)

3. Ye J, Yang J, Zheng J, Wong I, Ding X, Li W, Chen C, “Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump”, Proceedings of the 5th International Conference on Pumps and Fans (ICPF 2010), Hangzhou, China, October 18-21 (2010)

4. Liu G, Yang J, Zheng J, Wong I, Ding X, Xu C, Guo J, “The Fluid-Structure Interaction Analysis of Elbows under a Transient Liquid Slug”, Proceedings of the 5th International Conference on Pumps and Fans (ICPF 2010), Hangzhou, China, October 18-21 (2010)

5. Ye JJ, Yang J, Wong I, Ding XT, Zheng JY, Li WZ, Chen C, “Multiscale Dynamic Analysis on the Structure of a Porous Silicon-based Membrane for Micro-fuel Cells”, Proceedings of the 8th International Symposium on New Materials and Nano-materials for Electrochemical Systems, Shanghai, China, July 11-15 (2010)

6. Ye J, Yang J, Zheng J, Xu P, Lam CK, Wong I, Ma YB, “Effects of Wall Temperature on the Heat and Mass Transfer in Microchannels using the DSMC Method”, Proceedings of the 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2009), pp. 666 – 671, Shenzhen, China, January 5-8 (2009)

7. Wong PK, Tan W, Wong I, Ho C-M, “Microfluidics for Probing Cell-Microenvironment Dynamics”, in Proceedings of the International Conference on Bio-Nano-Informatics Fusion (BNIF 2005), Marina del Rey, USA, July 20-22 (2005)

Patentstop


Modeling and Optimization for Combinatorial Drug Therapy

1. An Integrated Experiment-Modeling Method to Optimizing Complex Systems Towards Desired State, UC Case No. UC2013-472, January 16, 2013, Ieong Wong, Xianting Ding, Chih-Ming Ho

Micro/Nanoscale Biochemical Surface Lithography

2. Synthesis of Uniform Agl Nanoparticles with Combinatorial Surfactants, US Application No. 61/509373, UC Case No. 2011-631, July 19th 2011, Ieong Wong, Jian Yang, Xianting Ding, Chih-Ming Ho

3. A Fast, High Throughput Method for Single Bacterial Patterning on Glass Surface, U.S. Application No. 61/559333, UC Case No. UC2011-042-1, November 14th 2011, Ieong Wong, Xianting Ding, Chih-Ming Ho

4. Self Assembled Monolayer Surface Patterning using a Molding Technique, US Application No. 60/760,509, International PCT No. PCT/US2007/001600, UC Case No. UC2006-371, January 22nd 2007¬¬, Ieong Wong, Chih-Ming Ho

Awards, Honors, and Scholarshipstop

• Nominated Member of Sigma Xi, The Scientific Research Society, 2009 – Present
• Graduate Departmental Fellowship and Scholarship (USD 20,000) for Distinguished Academic Records, 2004
summa cum laude, UCLA Department of Aerospace Engineering, 2003
• Outstanding Bachelor of Science Award, UCLA Department of Aerospace Engineering, 2003
• Southern California Aerospace Coordinating Committee Scholarship, USD 2500, 2002
• AMATYC Mathematic Contests Outstanding Achievements, 1999-2000
• Dean’s Honor List, School of Engineering and Applied Science, UCLA, 2001-2003
• Dean’s Honor List, Pasadena City College, Pasadena, California, 1999-2001

Contact Infotop

Mailing Address:
44-121 Engineering IV
420 Westwood Plaza
Los Angeles, CA 90095
Phone: 310-825-8275
Fax: 310-825-1350
Email: leffer at ucla.edu