Dr. Xianting Ding


I was born in Dalian, China. I went to Zhejiang University in Hangzhou, China, where I earned my B.S. degree in Automation Control. During my undergraduate studies, I found my research interest in studying complex systems. Complex systems such like biological systems, financial systems and human society are amazingly highly self-organized. Understanding and trying to control such systems is a tough but extremely exciting challenge to human beings. Fascinated by this enthusiasm, I joined Professor Chih-Ming Ho’s lab at UCLA in the summer of 2007 to continue my study as a Ph.D student in Mechanical Engineering. Under the supervision of Dr.Ho, I developed a rapid drug searching platform for combinatorial drug identification. This platform fuses engineering searching algorithms and biological experiments. With this platform, we identified the optimal drug cocktails for inhibiting Herpes Simplex Virus infection by testing less than 0.2% of the total possible drug combinations. I have also worked on synthesizing AgI nanoparticles using micro fluidics. Solid AgI nanoparticles are important electrolytes for next generation battery. Properly designing micro fluidics channels, we could synthesize uniform AgI particles at less than10 nm.

Research Intereststop


My research interests have been focused on understanding and controlling complex systems, particularly biological systems and chemical systems. Complex systems such like cells involve multiple layers of intracellular signaling molecules. These molecules interact in a highly dynamic nonlinear way. Traditional drug development usually targets on a particular molecule, such as a piece of DNA or RNA, a protein, an individual signaling receptor at cell membrane, etc. Due to the intrinsic cellular complexity, this route has resulted in a low yield of successful new drug cases of less than 1%. Meanwhile, to decide the target, traditional biologists commonly spend years of bench work. In our lab, we developed an effective and rapid solution to identify optimal drug combinations. This new platform combines an engineering searching algorithm and bench experiments. We applied this platform technique to various cases, including Herpes Simplex Virus inhibition, oral cancer therapy, osteogenic medium development and currently Chinese herbal medicine studies. Generally, we were able to identify effective drug cocktails by testing less than 0.2% of the total possible drug combinations. We also applied this platform technique to the synthesis of AgI nanoparticles in microfluidics. AgI nanoparticles are important electrolytes for next generation battery. By combining our search platform and microfliudics channels, we successfully synthesized uniform AgI nanoparticles at less than 10nm.

Educationtop

University of California, Los Angeles, Los Angeles, California, 2009–Now
Ph.D. in Mechanical Engineering, Major: Micro-Electro-Mechanical Systems/Nanotechnology
Advisor: Chih-Ming Ho, Ph.D.
Thesis: “A Top-down System Approach for Herpes Simplex Virus type 1 (HSV-1) inhibition”University of California, Los Angeles, Los Angeles, California, 2007–2009
M.S. in Mechanical and Aerospace Engineering

Zhejiang University, Hangzhou, China, 2003–2007
B.S. in Mechanical Engineering, Major: Automation

Work Experiencetop

Research Experience:Graduate Student Researcher (2007 – Now)
Mechanical and Aerospace Engineering Department, University of California, Los Angeles
• Developed an effective and rapid platform for identifying combinatorial drugs for Herpes Simplex Virus inhibition
• Developed surface chemical treatment to pattern single E.coli on glass surfaces
• Developed microfluidic systems to synthesize uniform AgI nanoparticles at < 10 nm

Undergraduate Student Researcher (2005 – 2007)
Mechanical Engineering Department, Zhejiang University, China
• Investigated liquid parameters using spinning liquid method
• Involved in building up an online laboratory (hardware part).

Publicationstop

Scientific Journal Articles:
1. Ieong Wong, Xianting Ding, Chunsheng Wu, Chih-Ming Ho “high accuracy bacteria immobiliation through thickened branched cationic polymer treatment on HMDS passivated glass surface,” in preparation
2. Xianting Ding, David Jesse Sanchez, Arash Shahangian, Genhong Cheng and Chih-Ming Ho, “Method of rapid screening combinatorial drugs for inhibiting HSV-1 infection,” in preparation
3. Hideaki Tsutsui, Bahram Valamehr, Antreas Hindoyan, Rong Qiao, Xiangting Ding, Shuling Guo, Rachel Kim, April Pyle, Amander Clark, Owen N. Witte, Xin Liu, Chih-Ming Ho and Hong Wu, “An Optimized Small Molecule Inhibitor Cocktail Supports Long-Term Maintenance Of Human Embryonic Stem Cells,” Nature Communication, doi:10.1038/ncomms1165, 2011
4. Jianjun Ye, Jian Yang, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, “A multi-scale flow analysis in hydrogen separation membranes using a coupled DSMC-SPH method,” International Journal of Hydrogen Energy (2011), doi:10.1016/j.ijhydene.2011.03.163
5. Liu Gang, Yang Jian, Zheng Jin-Yang, Ding Xianting, Wong Ieong, Xu Chao, Guo Jin-Xing, “The fluid-structure interaction analysis of elbows under a transient liquid slug,” Journal of Engineering Thermophysics, Vol 31, pages 85-88Conference Proceedings and Presentations:
6. Xianting Ding, David Jesse Sanchez, Arash Shahangian, Genhong Cheng and Chih-Ming Ho, “Ablation of HSV-1 Replication by Drug Combinations Developed through Feedback System Control,” Biomedical Engineering Society (BMES) Annual Meeting, October, 2010, Austin, TX
7. David Jesse Sanchez, Xianting Ding, Eric Schopf , Yang Liu, Jane C. Deng, Siyin Yang, Yong Cheng, Chih-Ming Ho, and Genhong Cheng, “Harnessing Nanotechnology to Create New Diagnostics and Treatments for Infectious Disease,” Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference, 10.1109/NANO.2010.5697737 , Date:17-20 Aug. 2010 , Seoul, Korea
8. Jianjun Ye, Jian Yang, Ieong Wong, Xianting Ding, Jinyang zheng ,Weizhong Li, Cong Chen, “Multiscale Dynamic Analysis on the Structure of a Porous Silicon-based Membrane for Micro-fuel Cells,” 8th International Symposium on New Materials for Electrochemical Systems, July 11 – 15, 2010, Shanghai, China
9. Yoshitomo Honda, Federico Mussano, Akira Wiberg, Xianting Ding, Chih-Ming Ho, Ichiro Nishimura, “Rapid Identification of combinatory osteogenic cocktails for mesenchymal stem cells”. International association for dental research (IADR) 89th Annual meeting, in San Diego, CA USA, March 16-19, 2011.
10. YE Jianjun, YANG Jian, ZHENG Jinyang, DING Xianting, WONG Ieong, LI Weizhong, CHEN Cong, “Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump,” 2010 International Conference on Pumps and Fans (2010 ICPF), 18-21 October, 2010,Hangzhou, Zhejiang, China
11. YE Jianjun, YANG Jian, ZHENG Jinyang, DING Xianting, WONG Ieong, LI Weizhong, CHEN Cong, “Research on the physical characteristics of the heat and mass transfer for micro-fluidic flow,” Pumps and Fans, 2010 (in Chinese)
12. Xianting Ding, David Jesse Sanchez, Arash Shahangian, Genhong Cheng and Chih-Ming Ho, “Feedback Control Algorithm in Rapid Combinatorial Drug Development–Pathway of Engineering to Nanomedicine”, Tech Forum, UCLA, Los Angeles, CA, March, 2011

Contact Infotop

Mailing Address:
18-111 Engineering IV
420 Westwood Plaza
Los Angeles, CA 90095Phone: 310-825-1350
Fax: 310-825-1350
Email: dingxianting@ucla.edu