Vita
My
favorites: Science, Cat and Chorus! If you are interested in any one of them,
welcome to discuss with me at pufrada_at_gmail_dot_com or visit my personal webpage.
Current Research
mRNA
and protein detection in Saliva system: For rapid and simple diagnostic, Saliva
is very promising. It’s non-invasive and easy to manipulate which make it
possible for home detection. Although saliva is not the main part of our body
fluid, both mRNA and protein biomarkers in saliva show saliva can act as a
diagnostic fluid not only for the oral disease, but also for other systematic
disease. The key point is how to detect tiny amount of mRNA or protein in
saliva WITHOUT purification and amplification. My current research is about the
electrochemical array for mRNA and protein in the mixture of saliva. The whole
system is combination of micro-fluidics, MEMs and
electrochemistry, which integrates the automatic sample loading, array of
electrochemical sensor and signal analysis.
“The magic is in your mouth.”
Education
- September, 1998 – July, 2003 Ph.D. candidate in
Chemistry at the College of Chemistry and Molecular Engineering,
, Beijing, P. R. China
- September, 1994 - July, 1998 B.A. student in the
Department of Chemistry ,
Work Experience
- 2003-2006 Assistant Professor,
Patents
*Fang Wei, Bernhard Zimmermann, David T. Wong, Chih-Ming Ho.
High specificity and high sensitivity detection based on steric hindrance & enzyme-related signal amplification, US Patent 60/941,057 (pending)
1. ZHAO X, WEI F
CN1477210-A 2004-390998
Gene chip potential Scanning no-mark fluorescence
detection method
2. ZHAO X, WEI F,
SUN B CN1373228-A 2003-141480
Gene chip for recognizing full match and
single-point mismatch, comprises hairpin-shaped probes having a detecting
region and a stem region
Selected Publications (for more information, FangWei's full CV)
After 2007
1. Fang Wei, Bernhard G. Zimmermann, Jianghua Wang, David T. Wong, Chih-Ming Ho., “Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with hairpin probe”, Nucleic Acid Research, in press
2. Fang Wei, Bernhard Zimmermann, Na Li, Chih-Ming Ho, David Wong, Electrochemical Detection of Salivary RNA, IEEE Review on Advances in Micro, Nano and Molecular Systems,7th IEEE International Conference on Nanotechnology, Hong Kong, Aug 2-5, 2007
3. Antoine Blin, Fang Wei and Chih-Ming Ho. A Facile Immuno-sensor with Surface Property Control by Conducting Polymer, IEEE international Conference on Nano/molecular Medicine and Engineering Conference, Macau, Aug 6-9.
Before 2007
1.
Wei, F, Peng Qu, Lin Zhai,
Chunlai Chen, Haifang Wang,
Xin Sheng Zhao
Electric potential induced dissociation of
hybridized DNA with hairpin motif immobilized on silicon surface
Langmuir. 2006; 22(14); 6280-6285
2.
Wei, F., C.
L. Chen, L. Zhai, N. Zhang, and X. S. Zhao.
Recognition of single
nucleotide polyrnorphisms using scanning potential
hairpin denaturation.
J. Am.
Chem. Soc. 127:5306-5307. 2005.
3.
Wei, F., B.
Sun, Y. Guo, and X. S. Zhao.
Monitoring DNA hybridization on alkyl modified
silicon surface through capacitance measurement.
Biosens. Bioelectron.
18:1157-1163. 2003.
4.
Wei, F., B. Sun, W. Liao, J. H. Ouyang, and X. S. Zhao.
Achieving differentiation of
single-base mutations through hairpin oligonucleotide
and electric potential control.
Biosens. Bioelectron. 18:1149-1155. 2003.
5.
Wei, F., and X. S. Zhao.
The capacitance of mixed alkyl monolayers on Si(111) surface.
Thin
Solid Films 408:286-290. 2002.
Awards, Honors
and Scholarships
- Award for Creative Ph. D. Thesis (with sustention fund), 2001
- Award for Outstanding Ph.D in Dept.
Chemistry,
- Teaching Award for Young Faculty,
Contact Info
Mailing Address:
44-121 Engineering IV
420
Phone:310-825-8275
Fax:310-825-1350
Email: frada@ucla.edu